The Welshside will be hoping to get back to winning ways after losing back-to-back games against Tottenham Hotspur and Norwich City. Michael Laudrup's side are currently 10th in the table.
Manchester United come into this game with a six-point lead over title rivals Manchester City at the top of the table. The Red Devils are on a run of five league wins recently a comfortable 3-1 victory over Sunderland.
Swans Dutch stopper Michel Vorm is set to return from a groin injury after being sidelined for nearly eight weeks. Spanish winger Pablo Hernandez returns after a thigh injury.
Meanwhile, Phil Jones will continue at right-back for United after Rafael missed the clash against Sunderland. The Brazilian is currently injured with a hamstring problem.
*Swansea last beat Manchester United in Jan 1982.
Swansea City (4-2-3-1): Tremmel-Rangel, Chico, Williams, Davies-Britton, Ki, Dyer, de Guzman, Routledge-Michu.
Manchester United (4-4-2): De Gea-Smalling, Vidic, Ferdinand, Evra-Valencia, Cleverley, Carrick, Young-Rooney, Van Persie.