United players eye revenge after Sunderland fans mocked them for losing the title to Manchester City at the Stadium of Light last season. The Black Cats last win at Old Trafford came in 1968, the day United lost the title to Manchester City.
Ferguson will be hoping his men know the importance of this fixture and with the return of captain Nemanja Vidic, after an absence of three months, he wouldn't like to see his team go down first for the 11th time this season.
Sunderland's 3-0 win over Reading helped them get out of the relegation zone but as for any other team visiting Old Trafford, Martin O'Niell's side will have their work cut-out against the league leaders.
However, United welcome back Vidic following his knee surgery while Jonny Evans misses out with a hamstring injury and Shinji Kagawa will face a fitness test.
Sunderland could make two changes on Saturday as winger Adam Johnson and left-back Danny Rose could miss out after picking injuries but defender Phil Bardsley and captain Lee Cattermole will be out of action.
*Manchester United are unbeaten in their last 20 league standings against Sunderland.
*Sunderland's last league win over United came in 1997.
Manchester United (4-2-3-1): De Gea-Jones, Smalling Vidic, Evra-Carrick, Scholes, Young, Rooney-Van Persie, Welbeck.
Sunderland (4-4-2): Mignolet-Gardner, O'Shea, Cuellar, Kilgallon-Vaughan, Larsson, Colback, McClean-Sessegnon, Fletcher.