Manchester United travel to their 'noisy neighbors' with a lead of three points at the top of the table. City, on the other hand, remain unbeaten so far but have not played the way champions usually do.
United have conceded the first goal on many ocassions, pointing fingers at their slack defence but the attack comes up with superb performance providing cover.
Both teams have not been at their best this season. However, City's exit from Europe won't deter their performance instead it would only make them stronger against their fierce rivals and considering their unbeaten record at the Etihad, City will definitely be confident.
Meanwhile, United boss Sir Alex Ferguson has warned his defence after seeing his side comeback from a losing position seven times in the league. United wouldn't mind a draw and staying ahead with three points but last years results will still haunt the Red Devils.
United were thrashed 6-1 at Old Trafford while Vincent Kompany completed the double with a single goal at the Etihad.
David Silva is in contention for a start despite missing the midweek Champions League loss to Borussia Dortmund. The Spanish playmaker suffered a hamstring injury. Left-back Aleksandar Kolarov is ruled out while Gael Clichy faces late fitness tests and James Milner is doubtful.
Ferguson ruled out Japan international Shinji Kagawa for Sunday's derby due to a knee injury while Nemanja Vidic won't be risked despite returning to training. Tom Cleverley will have a scan on his injured calf.
*Manchester United have conceded first 15 out of 23 matches across all competitions but have comeback to win seven times, a record in the Premier League.
*Manchester City are still unbeaten in the Premier League this season and have the best defensive record.
Manchester City (4-2-3-1): Hart-Zabaleta, Kompany, Natstasic, Clichy-Y Toure, Barry-Silva, Tevez, Nasri-Aguero.
Manchester United (4-2-3-1): De Gea-Rafael, Evans, Ferdinand, Evra-Carrick, Fletcher-Welbeck, Rooney, Young-Van Persie.