Currently 10th in the league, the Gunners are facing their worst start under Arsene Wenger in 18 years. Arsenal will be hoping to get back to winning ways after suffering a shock 2-0 defeat to Swansea City at home last time out.
The Baggies will look to take advantage of Arsenal's current form but having lost two in a row, West Brom need to win to enjoy their current standings in the league.
After 15 games and only 21 points, Arsenal are currently five points and five places below their weekend's opponents.
Gunners boss Arsene Wenger rested several key players during the 2-1 loss to Olympiakos in midweek but all are expected to return for the crucial clash against the Baggies.
However, two wingers will miss Saturday's clash, Theo Walcott and Lukas Podolski, both suffering calf injuries. Alex Oxlade-Chamberlain could start ahead of Walcott.
Meanwhile, West Brom strikers Romelu Lukaku and Peter Odemwingie could make the starting XI after starting on the bench against Stoke City last week.
* This is Arsenal's worst start to a Premier League season in 18 years.
Arsenal (4-3-3): Szczesny-Mertesacker, Vermaelen, Jenkinson, Gibbs-Arteta, Wilshere, Cazorla-Oxlade-Chamberlain, Giroud, Gervinho.
West Brom Albion (4-4-2): Myhill-Reid, Olsson, Popov, McAuley-Yacob, Dorrans, Mulumbu, Gera-Rosenberg, Long.