Tipped as the biggest match of the season, United travel to their 'noisy neighbours' home with a three-point lead over the defending champions.
Although City did the double over their fierce rivals and winning the league virtually at the last kick of the season, Roberto Mancini's men haven't been in similar form this time out.
However, City are still unbeaten in the league and hold the perfect record at home, remaining unbeaten for over two years.
Meanwhile, United rely on their strong strike force to provide cover for slack defending.
City, once a mid-tabled team, have now emerged serious title contenders alongside United and the Manchester derby has turned out be one of the biggest matches in the Premier League.