Mark Hughes has been sacked after QPR failed to win a single game after 12 matches. The Londoners are currently at the bottom of table with just four points and are unlikely to get a positive result in Manchester. Harry Redknapp will take over Rangers but the former Spurs boss will watch his new side from the stands as assistant manager Mark Bowen will lead the Londoners at Old Trafford.
Meanwhile, United have lost back-to-back matches, recently suffered a 1-0 loss in the Champions League on Tuesday. Manager Sir Alex Ferguson fielded a young squad in Istanbul but the likes of Wayne Rooney, Robin van Persie, Rio Ferdinand and Patrice Evra are expected to make the first team.
QPR, on the other hand, have second-worst defence in the league while United will look to regain their top-spot for a day at least as rivals Manchester City travel to Chelsea.
Phil Jones played his first match of the season in midweek but Ferguson could play Jonny Evans and Ferdinand in the heart of defence.
Rooney missed the loss against Norwich but is set to return on Saturday while Shinji Kagawa remains United's long-term absentees along with defender Nemanja Vidic.
QPR are left with one senior striker in Djibril Cisse after Bobby Zamora was ruled out for the rest of the season while Andy Johnson is still sidelined.
*The last time these two sides met at Old Trafford, Manchester United won 2-0.
*Robin van Persie is United's top-scorer with eight goals in 12 games.
*QPR have scored nine and conceded 23 goals so far this season.
Manchester United (4-2-3-1): De Gea-Rafael, Evans, Ferdinand, Evra-Cleverley, Carrick-Young-Valencia, Rooney-Van Persie.
Queens Park Rangers (4-3-3): Julio Cesar-Bosingwa, Nelsen, Diakite, Traore-Park, Granero, M'Bia-Hoilett, Cisse, Taarabt.