The English champions are in desperate need of a win to avoid a second successive elimination from group stages while Jose Mourinho's side will seal a place in the knockout stages with a win or draw, depending on the result of other group match between Ajax and Borrusia Dortmund.
Though Mourinho admitted it is end of City's European campaign, manager Roberto Mancini remains optimistic against the 'one of the best teams in the world.'
Mourinho, the most successful manager in the competition, will take charge of his 100th game in Europe's elite competition and would expect his side to emerge winners against the 'under pressure' Citizens.
However, City are unbeaten in 19 European home matches after coming back from losing position against Dortmund and Ajax. The recent 5-0 thrashing of Aston Villa in the league should definitely lift their confidence but such slim chances could dampen their spirits against the nine-time competition winners.
Moreover, only two teams have recovered from a position as Manchester City's to qualify for the last-16, Lokomotiv Moscow with one point in 2002-03 and Porto with two points in 2004-05.
Meanwhile, Gael Chichy's injury means Aleksander Kolarov will play at left-back while joleon Lescott and James Milner still remain sidelined.
Defender Micah Richards remains a long-term absentee with a knee injury.
Mourinho's Real side have no fresh injuries but Gonzalo Higuain and Marcelo are major doubts for the visitors.
*Manchester City are unbeaten in 19 European home games.
*Real Madrid have conceded 499 goals in the UEFA Champions League, group stage to finals and gave scored 946.
*In matchday 1, Real came back to beat City 3-2 at the Santiago Bernabeu.
Manchester City (4-4-2): Hart-Zabaleta, Kompany, Nastasic, Kolarov-Nasri, Y Toure, Barry, Silva-Tevez, Aguero
Real Madrid (4-2-3-1): Casillas-Arbeloa, Ramos, Pepe, Coentrao-Khedira, Alonso-Di Maria, Ozil, Ronaldo-Benzema