A win for either side could take them to the top half of the table and while Wigan beat the Reds at home last season, Brendan Rodgers will hope his side can gather some momentum ahead of tough away league games.
Rodgers could yet again depend on in-form Luis Suarez to pull the strings after a fine show against Poland away at national duty, scoring and providing for Edinson Cavani.
Liverpool are likely to return to their usual 4-3-3 after opting for more defensive setup against Chelsea. But Daniel Agger and Martin Skrtel are fighting to be fit for this crucial clash at Anfield.
Skrtel missed the last game at Stamford Bridge due to a virus while Agger missed Denmark's friendly game against Turkey in midweek. Rodgers is likely to hand Pepe Reina a start after a month's absence due to hamstring injury or he would stick to Brad Jones who has had a decent performance so far.
Jonjo Shelvey is expected to recover from a knee problem while Fabio Borini, Martin Kelly and Lucas Leiva remain long-term absentees for the Reds.
Wigan boss Roberto Martinez is likely to retain the same squad for third time in a row but Spaniard hopes to take Ryo Miyaichi to Anfield after suffering a groin injury.
Goalkeeper Ali Al-Habsi returns despite concerns of a shoulder problem while James McArthur is unlikely to feature with a thigh injury.
*Luis Suarez has scored eight Premier League goals this season, joint top-scorer in the league.
*Wigan Athletic's win over Liverpool at Anfield last season was their first-ever away victory over the Reds.
*Liverpool and England captain Steven Gerrard became the sixth player to reach 100 caps for the national side.
Liverpool (4-3-3): Reina-Wisdom, Skrtel, Agger, Johnson-Gerrard, Allen, Sahin-Suso, Suarez, Sterling.
Wigan Athletic (3-5-1): Al-Habsi-Ramis, Caldwell, Figueroa-Boyce, Watson, McCarthy, Beausejour, Maloney, Kone-Di Santo.