Reading still search for their first win this season as they take on Stoke City and Norwich City, respectively. Elsewhere, Everton host draw specialists Sunderland, under-fire Southampton host Swansea, West Brom face Wigan at the DW Stadium.
Everton vs Sunderland - Goodison Park
Everton have drawn their last four games in the Premier League and host draw specialists Sunderland at Goodison Park on Saturday.
David Moyes hopes his side can earn three points against the Black Cats who last won away back in February.
Everton are without right-back Tony Hibbert, midfielder Darren Gibson and striker Victor Anichebe while Sunderland are likely to retain the same squad which started against Aston Villa.
*If Everton draw again, it will be the first time they have drawn five consecutive games.
Everton (4-4-2): Howard-Coleman, Jagielka, Heitinga, Baines-Mirallas, Neville, Osman, Pienaar-Fellaini, Jelavic.
Sunderland (4-4-2): Mignolet-Bardsley, O'Shea, Cuellar, Rose-Larsson, Cattermole, Gardner, Johnson-Fletcher, Sessegnon.
Reading vs Norwich City - Madejski Stadium
The Canaries have certainly improved at home after beating Arsenal, Tottenham and Stoke City but yet to win an away game this season while Reading have not won a game in the league.
Royals will miss Jem Karacan and Danny Guthrie while goalkeeper Adam Federici could return after Alex McCarthy was ruled out. Meanwhile, Norwich defender Russell Martin will face a fitness test.
*Reading are yet to win this season while Norwich have struggled away from home, losing all on the road.
Reading (4-4-2): Federici-Gunter, Morrison, Gorkss, Shorey-McCleary, Tabb, Leigertwood, McAnuff-Hunt, Pogrebnyak.
Norwich City (4-2-3-1): Ruddy-Whittaker, Bassong, Turner, Garrido-Tettey, Johnson-Snodgrass, Hoolahan, Pilkington-Holt.
Southampton vs Swansea City - St Mary's Stadium
Under pressure, boss Nigel Adkins still searches for a win this campaign as the Saints host tricky opponents Swansea at St Mary's Stadium on Saturday.
Michael Laudrup too came under criticism over tactics and management but his players have settled with a point against Chelsea.
*Southampton have lost 8 out of 10 league games this season.
Southampton (4-4-2): Boruc-Clyne, Yoshida, Fonte, Fox-Schneiderlin, S Davis, Lallana, Ramirez-Lambert, Rodriguez.
Swansea City (4-2-3-1): Tremmel-Rangel, Monk, Williams, Davies-Britton, Ki-Hernandez, De Guzman, Routledge-Michu.
Stoke City vs Queens Park Rangers - Britannia Stadium
Yet to win this season, QPR manager Mark Hughes is under pressure as his side visit the Britannia to face a tough Stoke City side.
While Stoke have drawn six games and lost three, three points will be vital for both sides going into this game.
The Potters are without Rory Delap, Michael Owen and long-term absentee Marc Wilson while QPR are without suspended Stephane Mbia, captain Park Ji-Sung, Fabio and Andre Johnson.
*QPR have lost six and drawn four games this season.
Stoke City (4-2-3-1): Begovic-Cameron, Huth, Shawcross, Wilkinson-Whitehead, Nzonzi-Walters, Adam, Kightly-Crouch.
QPR (4-4-2): Julio Cesar-Bosingwa, Ferdinand, Nelsen, Traore-Mackie, Granero, Diakite, Taarabt-Hoilett.
Wigan Athletic vs West Brom Albion - DW Stadium
After winning at White Hart Lane against Tottenham, Wigan are confident ahead of the clash with West Brom Albion, who are currently fifth on the table.
With back-to-back wins, Wigan have the upperhand in this fixture considering the Baggies record at the DW, failing to beat the Latic in four years.
*Only 11 goals have been scored in eight meetings between the two sides at DW Stadium, with the home side scoring seven.
Wigan Athletic (4-3-3): Al Habsi-Boyce, Ramis, Caldwell, Figuero-McCarthy, Watson, Beausejour-Maloney, Kone, Di Santo.
West Brom Albion (4-2-3-1): Myhill-Jones, McAuley, Olsson, Ridgewell-Morrison, Mulumbu-Odemwingie, Gera, Dorrans-Long.