The Gunners suffered a 2-1 loss to fierce rivals Manchester United last weekend before giving away a two-goal lead in Germany against Schalke in the UEFA Champions League group stage match.
Placed seventh in the League, Arsene Wenger's side slipped to three defeats in their last five games but will be confident with the impressive home record against the Cottagers.
Fulham have never won at Arsenal in 26 attempts, losing 22 and drawing four but Martin Jol's side won 2-1 at home last season.
Arsenal hope first-choice goalkeeper Wojciech Szczesny is fit to play after training with side while midfielder Jack Wilshere misses out due to his suspension for the red card against Manchester United.
Winger Alex Oxlade Chamberlain and midfielder Aaron Ramsey face late fitness test for the Premier League clash.
Meanwhile, Fulham midfielder Mahamadou Diarra is doubtful for the trip to Emirates, facing a late fitness test to play against the Gunners. Manager Jol revealed Diarra is 50-50 to face Gunners.
*After 10 games, Arsenal have made their worst start under Arsene Wenger.
Arsenal (4-3-3): Mannone-Sagna, Mertesacker, Koscielny, Vermaelen-Arteta, Ramsey-Cazorla-Walcott, Giroud, Podolski.
Fulham (4-4-2): Schwarzer-Riether, Hughes, Hangeland, Riise-Duff, Baird, Sidwell, Diarra-Ruiz, Berbatov.