Manchester United hope to seal qualification for the knockout stages but Sporting Braga have won their last four home games against Premier League teams.
Jose Peseiro's side will aim to spoil United's progress having won four home games against English opponents. Braga gave away a two-goal lead at Old Trafford losing 3-2 last time out.
Despite having the likes of Wayne Rooney and Robin van Persie, Braga were the first to score, going ahead with two goals through captain Alan. But the Red Devils are in firing form recently beating heavyweights Arsenal and Chelsea in the domestic league.
However, the Portuguese are not going to give up without putting up a strong fight while United would anticipate the threat, Braga would go guns on sealing three points to finish second in Group H.
Braga, who host United for the first time, are free of fresh injuries as left-back Douglao returned to action while Paulo Vinicius and Paulo Cesar remain sidelined with thigh injuries.
Meanwhile, Chris Smalling, who has not played a game this season due to a foot injury, has travelled to Portugal while Shinji Kagawa, Phil Jones and Nemanja Vidic are still absent.
*Manchester United will play their 300th game in UEFA competitions.
*Robin van Persie has scored five goals in his last six games in UEFA Champions League.
*Manchester United have lost 45 games in the competition.
Sporting Braga (4-4-2): Beto-Baiano, Coelho, Echiejile, Douglao-Custodio, Mossoro, Viana, Alan-Barbosa, Eder.
Manchester United (4-4-2): De Gea-Rafael, Evans, Ferdinand, Buttner-Cleverley, Carrick, Fletcher, Welbeck-Rooney, Van Persie.