Spurs are favourite against the side whom they thrashed 9-1 two seasons ago but Wigan were the only team to have won at White Hart Lane last season.
Roberto Martinez's men will try to snatch a point and end their three-game losing streak away from home while Spurs will hope to hold on to the fourth spot with three points.
Wigan do not have fresh injury concerns but Japanese winger Ryo Miyaichi is sidelined with a groin injury and unlikely to be fit for the clash against Spurs.
*Tottenham beat Wigan 9-1 during the 2009-10 season, Jermain Defoe scored five goals.
*Wigan have won just once in four matches at White Hart Lane.
Tottenham Hotspur (4-4-2): Friedel-Walker, Gallas, Caulker, Vertonghen-Lennon, Sigurdsson, Sandro, Bale-Dempsey, Defoe.
Wigan Athletic (3-5-2): Al-Habsi-Ramis, Caldwell, Figueroa-Boyce, McArthur, McCarthy, Beausejour-Maloney-Kone, Di Santo.