Everton face a tricky visit to the Craven Cottage against Fulham, in-form Norwich City host Stoke City, with poor winning record recently, both Aston Villa and Sunderland hope to their miserable form, league leaders Chelsea visit Welsh side Swansea.
Fulham vs Everton - Craven Cottage
Both sides have enjoyed equal success with four wins this season and a win for either side would take them to fourth place in the Premier League.
Fulham lost against Manchester City at the Cottage, their only home defeat in five games, while Everton drew their last two games on the road.
Chris Baird returns for the Londoners while Kevin Mirallas will face a late test. Playmaker Steven Pienaar returns after suspension.
*Everton have lost just one away game this Premier League season.
Fulham (4-4-2): Schwarzer-Riether, Hughes, Hangeland, Riise-Duff, Baird, Diarra, Richardson-Rodallega, Berbatov.
Everton (4-4-2): Howard-Coleman, Jagielka, Distin, Baines-Mirallas, Neville, Osman, Pienaar-Fellaini, Jelavic.
Norwich City vs Stoke City - Carrow Road
The Canaries will be confident after two home wins in a row against two North London clubs Arsenal and Tottenham Hotspur. Stoke City will have a tough time at Carrow Road with their poor away form.
The Potters have not won away from since January, a total of 14 league games. However, Norwich hopes to stay clear from the relegation zone.
Norwich defender Russel Martin could be in for a start while Stoke miss out on Marc Wilson. Midfielder Glenn Whelan is declared fit again.
*Both teams have won one league game in nine this season.
Norwich City (4-5-1): Ruddy-R Martin, Bassong, Turner, Garrido-Tettey, Johnson-Pilkington, Hoolahan, E Bennett-Holt.
Stoke City (4-4-2): Begovic-Cameron, Shawcross, Huth, Wilkinson-Etherington, When, Adam, Kightly-Walters, Crouch.
Sunderland vs Aston Villa - Stadium of Light
Two teams with a miserable winning record clash heads at the Stadium of Light. A single win for the home side in 16 games while Aston Villa have won one in 19.
Wes Brown is still out for the Black Cats along with defender Titus Bramble. For the Villans, Karim El Ahmadi will serve a one-match ban after being booked five times while Chris Herd is doubtful to start.
*Both teams have won only one game this season.
Sunderland (4-5-1): Mignolet-Gardner, O'Shea, Cuellar, Rose-Johnson, Larsson, Cattermole, Colback, McClean-Fletcher.
Aston Villa (4-5-1): Guzan-Lowton, Clark, Vlaar, Baker-Delph, Ireland-Albrighton, Holman, Agbonlahor-Benteke.
Swansea City vs Chelsea - Liberty Stadium
Both teams are coming from victories during the Capital One Cup clash in midweek. Table toppers Chelsea aim to keep their place while the Swans hunt for their third home win.
Swansea defender Chico Flores is in contention for a starting place despite having a deal leg at Anfield. For Chelsea, David Luiz and Juam Mata could miss the clash after suffering injuries while playing 120 minutes against Manchester United.
Fernando Torres and Branislav Ivanovic return from their one-match suspension while Frank Lampard remains sidelined, John Terry serves the final match of his suspension.
*Chelsea have won only twice at Swansea, in 1981 and 1928.
Swansea City (4-4-2): Tremmel-Rangel, Chico, Williams, Davies-Hernandez, Ki, Britton, Routledge-De Guzman, Michu.
Chelsea (4-5-1): Cech-Azpilicueta, Ivanovic, Cahill, Cole-Romeu, Mikel-Ramires, Oscar, Hazard-Torres.
Queens Park Rangers vs Reading FC - Loftus Road
Hanging in the relegation zone, both teams look to climb up the table with QPR under more pressure having failed to win a single match so far while Reading will hope to comeback from their 5-7 Capital One Cup defeat to Arsenal.
Brian McDermott's side have a game in hand but are still searching for their first win this campaign.
QPR captain Park Ji-Sung, Bobby Zamora and Armand Traore are doubtful while Stephane Mbia serves first of his three-match suspension for a red card against Arsenal.
*QPR have their worst start to the season since 1968.
Queens Park Rangers (4-4-2): Julio Cesar-Bosingwa, Ferdinand, Nelsen, Onuoha-Wright-Phillips, Granero, Taarabt, Diakite-Cisse, Hoilett.
Reading (4-4-2): McCarthy-Cummings, Gorkss, Mariappa, Shorey-Kebe, Tabb, Leigertwood, McAnuff-Roberts, Pogrebnyak.