The Blues boast an impressive home record against the Red Devils with six wins and four draws in their last 10 encounters. United striker Robin van Persie will be keen to end that hoodoo as he scored a hat-trick for Arsenal and remains the highest scorer at Stamford Bridge.
Roberto Di Matteo's side will be hoping to bounce back from their loss against Shakhtar Donetsk in the UEFA Champions League while the Red Devils have been unbeaten since their shock defeat to Tottenham at Old Trafford.
Both sides have injury concerns to key players as Chelsea will miss veteran Frank Lampard who will be sidelined for two weeks with a calf injury. The 34-year old is set to miss the Capital One Cup clash against United.
John Terry is currently serving his four-match suspension which means Gary Cahill will partner David Luiz in the heart of defence.
Meanwhile, United playmaker Shinji Kagawa is set to miss the clash against Chelsea with a knee injury. Javier Hernandez is likely to start after his double against Braga in the Champions League on Tuesday.
*Chelsea's home record against Manchester United in their last 10 meetings read W6 D4 L0.
*United have conceded first in eight out of 12 games this season.
Chelsea (4-2-3-1): Cech-Ivanovic, Luiz, Cahill, Cole-Ramires, Mikel-Hazard, Oscar, Mata-Torres
Manchester United (4-3-3): De Gea-Rafael, Ferdinand, Evans, Evra-Valencia, Carrick, Nani-Rooney-Welbeck, Van Persie.