Both sides hit with injuries to key players clash heads to decide who goes on top of 'Group of Death' in the UEFA Champions League.
Jose Mourinho will play Sergio Ramos and Michael Essien on either flanks while Jurgen Klopp's side face major doubts on Ilkay Gundagon, playmaker Mario Gotze and Marcel Schmelzer.
Real midfielder Sami Khedira returns to the starting XI after missing out the weekend clash against Celta while Angel Di Maria, Luka Modric and Mesut Ozil will fight for a place in the team.
Meanwhile, Dortmund have never beaten Real in their last four attempts while the Bundesliga champions have failed to win any of their last five home encounters with Spanish clubs.
*Real Madrid's away record against German opposition reads (W1 D6 L16).
*Crisitano Ronaldo has scored four goals in two games including a hat-trick.
Borussia Dortmund (4-2-3-1): Weidenfeller-Piszczek, Subotic, Hummels, Schmelzer-Bender, Kehl-Gotze, Reus, Grosskreutz-Lewandowski
Real Madrid (4-3-2-1): Casillas-Ramos, Varane, Pepe, Essien-Khedira, Alonso-Di Maria, Ozil, Ronaldo-Benzema