Fulham, West Brom entertain champions City, Swansea look to end winless run against Wigan, Gunners look to clinch three points against helpless Norwich while Southampton hope to end their struggle at Upton Park against West Ham
Here's the Preview for Game Week 8:
Fulham vs Aston Villa - Craven Cottage
Aston Villa hope to avoid a relegation spot when they face a stern test against Fulham at the Craven Cottage.
Dimitar Berbatov is expected to return for Fulham while Darren Bent has to fight for his place in the squad according to Villa manager Paul Lambert.
*Aston Villa's worst ever start to a campaign with five points in seven games.
*Fulham have a poor record against the Villans. In their last six meetings, the Cottagers have lost three and drawn three.
Fulham (4-4-2): Scwarzer-Baird, Hughes, Hangeland, Riise-Duff, Sidwell, Riether, Kacaniklic-Berbatov, Rodallega.
Aston Villa (4-4-2): Guzan-Lowton, Vlaar, Clark, Bennett-Albrighton, El Ahmadi, Delph, Holman-Agbonlahor, Benteke.
West Brom Albion vs Manchester City - The Hawthorns
Injury-hit Baggies side take on Premier League champions Manchester City after their best home start since 1919 at the top-flight.
Chris Brunt, Steven Reid, Jerome Thomas and Billy Jones are sidelined for West Brom while Romelu Lukaku and Liam Ridgewell face late fitness tests.
For City, David Silva is a major doubt due to hamstring injury while Javi Garcia is expected to return after suffering a knock against Borussia Dortmund.
*West Brom have failed to score in their last four league games against City.
*The Baggies have won three of their last five games at home against City.
West Brom Albion (4-2-3-1): Foster-Tamas, McAuley, Olsson, Popov-Yacob, Dorrans-Odemwingie, Morrison, Gera-Long.
Manchester City (4-4-2): Hart-Richards, Kompany, Lescott, Kolarov-Milner, Yaya Toure, Garcia, Nasri-Tevez, Aguero.
Norwich City vs Arsenal - Carrow Road
Winless this season and lying in the relegation zone, Norwich take on an in-form Arsenal side at Carrow Road on Saturday.
Arsene Wenger's side are unbeaten in 12 visits to Carrow Road while Chris Hughton's men have won just one of their 12 league games.
*With only three points in seven games, Norwich have their worst ever start to a Premier League season.
Norwich City (4-5-1): Ruddy-Martin, Bassong, Barnett, Garrido, Johnson, Howson, E Bennett, Hoolahan, Surman-Holt.
Arsenal (4-3-3): Mannone-Jenkinson, Mertesacker, Vermaelen, Santos-Ramsey, Arteta, Cazorla-Gervinho, Giroud, Podolski.
West Ham United vs Southampton - Upton Park
The Saints have struggled so far this season while the Hammers are on course to their second-best start to a season in the Premier League era.
Hammers defenders Winston Reid and Guy Demel will face a fitness test to take on Southampton while Andy Carroll is expected to start upfront.
Major blow for Southampton would be their record signing winger Gaston Ramirez who is sidelined for nearly four weeks.
*Southampton have conceded 20 goals this season, the most by any side in the Premier League.
West Ham United (4-5-1): Jaaskelainen-Demel, Collins, Reid, McCartney-Taylor, Nolan, Diame, Noble, Jarvis-Carroll.
Southampton (4-4-2): Gazzaniga-Clyne, Fonte, Yoshida, Fox-Puncheon, Schneiderlin, S Davis, Lallana-Rodriguez, Lambert.
Swansea City vs Wigan Athletic - Liberty Stadium
No wins in six games has put Swansea manager Michael Laudrup under even more pressure as players complain about his management techniques. On the other hand, Wigan hope to win their second of the campaign at the Liberty stadium on Saturday.
The Welshside will be hoping to put an end to their winless run after clinching victories in their opening two games while Roberto Martinez's side have picked up five points in seven games.
*Michu has scored five goals from just seven shots on target this season.
Swansea City (4-5-1): Vorm-Rangel, Chico, Williams, Davies-Britton, Ki, Dyer, Michu, Routledge-Graham.
Wigan Athletic (3-4-3): Al-Habsi-Ramis, Caldwell, Figueroa-Boyce, McCarthy, McArthur, Beausejour-Maloney, Kone, Di Santo.