The Potters' poor away record against the Red Devils reads 11 losses and one draw since 1976 while Alex Ferguson's men will be keen to continue their impressive form following a 3-0 victory over Newcastle.
United welcome centre-back Chris Smalling and winger Ashley Young as Ferguson gets a much needed defensive boost against Tony Pulis' towering players. But Smalling will be given a late fitness test as Fergie is happy with Rio Ferdinand and Jonny Evans at the heart of the defence.
Stoke will check the condition of midfielder Glenn Whelan after the Irishman was hauled off against Liverpool with a hamstring injury. Forward Michael Owen, who missed the game against Liverpool, could be back on to face his former side but will have to settle on the bench.
United are clear favourites to win the game but Stoke City have drawn five games in seven. The Red Devils have not drawn a single game this season winning five and losing two.
*Stoke City have lost all eight in their last eight league visits to Old Trafford.
*The Potters have conceded 22 goals and scored just once in their last eight visits.
Manchester United (4-3-3): De Gea-Rafael, Ferdinand, Evans, Evra-Kagawa, Carrick, Cleverley-Rooney-Van Persie, Welbeck.
Stoke City (4-5-1): Begovic-Cameron, Shawcross, Huth, Wilson-N'Zonzi, Whelan-Walters, Adam, Kightly-Crouch.