The Red Devils take on Group H leaders CFR as the hosts started their European campaign with a win over Portuguese giants Braga in Game Week 1.
United come into this tie after losing the home game against Tottenham 3-2 in the Premier League while CFR have not lost a home game since 22nd July.
However, Fergie lauded his teams efforts during the second half against Tottenham. The 70-year-old Scot also pointed out CFR's danger man Rafael Bastos and their opponents counter attacking football.
United face usual problems at the back with key defenders injured namely Nemanja Vidic, Chris Smalling and Phil Jones. Winger's Antonio Valencia and Ashley Young are sidelined while Paul Scholes has been given a rest. Michael Carrick and veteran Ryan Giggs missed training due to a virus.
For CRF, Vasile Maftie returns after serving a one-game suspension while striker Pantelis Kapetanos could start after training with the first team.
*Manchester United have won 99 games in the Champions League.
*Ryan Giggs is competitions oldest scorer at 37 years and 289 days.
*CFR have scored 47 goals in UEFA competition.
CFR Cluj (4-5-1): Felguerias-Pinto, Cadu, Rada, Sepsi-Muresan, Alberto, Sougou, Bastos, Camora-Kapetanos.
Manchester Untied (4-3-3): De Gea-Rafael, Ferdinand, Evans, Buttner-Cleverley, Fletcher, Anderson-Nani, Rooney, Welbeck.