After five league games, both teams have managed to remain unbeaten with the Blues on top after keeping three consecutive clean sheets while Arsene Wenger's Gunners will look to continue their fine form in front of goal.
Wenger has to decide whether to include winger Theo Walcott or Ivorian Gervinho on the right flank. Walcott scored a double against Coventry City in the League Cup while Gervinho has scored thrice in all competitions this season.
Per Mertesacker looks set to be benched with the return of Belgian centre-back Thomas Vermaelen returning to action. The Gunners skipper will link up with Laurent Koscielny in defence.
Meanwhile, Roberto Di Matteo has a full squad to choose from. John Terry, who was recently handed a four-match ban after he was found guilty of racially abusing Anton Ferdinand, is likely to retain his place until the appeals process has been concluded.
Eden Hazard and Juan Mata are favourites to start in this high tempo game supporting lone striker Fernando Torres. Di Matteo will continue with the same line-up as several fringe players like Victor Moses, Oscar, Ryan Bertrand and Marko Marin wait for their turn.
*Both sides are unbeaten this season, with Chelsea on top and Arsenal on 5th place.
*Mikel Arteta will make his 250th start in English football while a win over Chelsea would hand Wenger his 350th win as Arsenal manager.
*Chelsea last conceded a goal against Reading, over a month ago.
Arsenal (4-3-3): Mannone-Jenkinson, Vermaelen, Koscielny, Gibbs-Diaby, Arteta, Cazorla-Gervinho, Giroud, Podolski.
Chelsea (4-3-3): Cech-Ivanovic, Terry, Cahill, Cole-Mikel, Lampard, Ramires-Hazard, Torres, Mata.