Alan Pardew's men beat the Red Devils 3-0 at home in the Premier League last season.
Both sides have a chance to give an opportunity to fringe players as United boss Sir Alex Ferguson is ready to hand left-back Alex Buttner and Nick Powell a start after scoring against Wigan.
Newcastle boss Pardew will hope skipper Fabio Coloccini passes the fitness test while midfielder Cheikh Tiote is expected to make his first start after a long injury lay off.
Red Devils skipper Nemanja Vidic will miss the clash after undergoing a knee surgery while makeshift right-back Antonio Valencia left the training ground on crutches.
Veteran centre-back Rio Ferdinand and Jonny Evans are set to partner each other in defence while Tom Cleverly and Anderson could start ahead of Paul Scholes and Michael Carrick.
Wayne Rooney remains a major doubt while striker Robin van Persie will be rested meaning Danny Welbeck and Javier Hernandez are set to start.
*Manchester United's Robin van Persie is the leading goal-scorer this season with five goals in five games in the Premier League.
*Newcastle have not won at Old Trafford in 40 years.
*United have won the League Cup four times while Newcastle have never won the Cup in their history.
Manchester United (4-4-2): De Gea-Rafael, Ferdinand, Evans, Buttner-Fletcher, Anderson, Powell-Cleverley-Chicharito, Welbeck.
Newcastle United (4-3-3): Harper-Perch, Williamson, S Taylor, Santon-Gosling, Tiote, Bigirimana-Obertan, Shola Ameobi, Amalfitano.