The Blues finally tasted European success last season in 10 attempts after beating Bayern Munich on penalties. The west London club last met their group opponents in 2008/09 season beating Juventus 1-0 in the first-leg and drawing 2-2 away at Turin.
Both teams remain unbeaten in their respective domestic leagues, however, Juventus are unbeaten in 42 Serie A games.
Chelsea defensive duo John Terry and Ashley Cole are set to make a comeback after missing England's game during the international break. Playmaker Juan Mata is set to clash against the Bianconeri alongside Eden Hazard and Ramirez.
The Old Lady will play a 3-5-2 formation but Brazilian centre back Lucio will miss the game with an ankle injury. However, Andrea Barzagli, Leonardo Bonucci and Giorgio Chiellini are set to form the defensive line.
*Chelsea won all six of their UEFA champions League home games last season, scoring 17 and conceding 2.
*Chelsea have conceded 97 goals in the UEFA Champions League, group stage to final.
*Juventus captain and goalkeeper Gianluigi Buffon will make his 400th appearance for the Old Lady if he features against Chelsea.
*Alessandro Del Piero left Juventus after making 705 appearances and scoring 289 goals, both club records.
Chelsea (4-3-3): Cech-Ivanovic, Cahill, Terry, Cole-Ramires, Mikel, Lampard-Hazard, Torres, Mata
Juventus (3-5-2): Buffon-Barzagli, Bonucci, Chiellini-Lichtsteiner, Pirlo, Asamoah, Vidal, Marchisio-Giovinco, Vucinic