The 70-year old Scot said he will name an experienced starting XI to avoid any careless mistakes which cost them last season.
Left-back Patrice Evra will have to fight for his place after an impressive show by dutch defender Alexander Buttner against Wigan Athletic during the weekend. Wayne Rooney is set to miss this clash alongwith winger Ashley Young. Former Arsenal captain Robin van Persie will lead the attack for United.
Galatasaray have began their domestic campaign in sublime form with three wins in four games. However, coach Fatih Terim has urged his players to up their game against one of the best teams in the world but said his side are capable of beating United.
Meanwhile, United have lost twice and drawn once against Turkish sides at Old Trafford. Besiktas were the last team to beat United at home in 2009-10.
*Manchester United are participating in their 17th successive Champions League group stage.
*Galatasaray are back in the Champions League after five seasons.
*United's 4-0 win over Wigan marked veteran midfielder Paul Scholes' 700th United appearance.
Manchester United (4-2-3-1): Lindegaard-Rafael, Vidic, Ferdinand, Buttner-Scholes, Carrick-Valencia, Kagawa, Nani-Van Persie
Galatasaray (4-3-3): Muslera-Eboue, Cris, Kaya, Balta-Melo, Inan, A Yilmaz-B Yilmaz, Elmander, Amrabat