The Los Blancos have had their worst start over 10 seasons after losing two in three matches with only four points in as many games. Jose Mourinho will hope his men will put an end to the miserable start to the season.
Describing Real as the best team in the world, City boss Roberto Mancini stressed upon starting well in what seems to be a 'complicated' Group D for the Italian.
However, Real new signings Michael Essien and Luka Modric have been included in the squad while Cristiano Ronaldo's 'unhappy' situation with the club continues to make headlines in Spain and abroad.
On the other hand, Mancinin may hand European debut to right-back Maicon as Micah Richards and Pablo Zabaleta are yet to be match-fit. Javi Garcia, who scored against Stoke City during the weekend may start along side Yaya Toure in midfield.
*Real Madrid are now eight points behind rivals Barcelona after four games.
*Real Madrid have won the UEFA Champions League a record nine times, the last time they won it back in 2001/02 under current Spain coach Vicente Del Bosque.
*Manchester City are yet to keep a clean sheet this season.
*Madrid have won 99 UEFA Champions League games, group stage to final, scoring 348 goals and conceding 194.
Real Madrid (4-2-3-1): Casillas-Arbeloa, Ramos, Pepe, Marcelo-Alonso, Khedira-Ozil, Modric, Cristiano Ronaldo-Benzema
Manchester City (4-2-3-1): Hart-Maicon, Kompany, Lescott, Clichy-Yaya Toure, Javi Garcia-Silva, Nasri, Tevez-Aguero