Tottenham are currently 16th in the League table with two points in three games. Spurs must find a way to beat Brian McDermott's team who have not tasted defeat at home since January, remaining unbeaten for 10 league games.
Clint Dempsey, who signed for Spurs on transfer deadline day, is likely to get his first start while the manager insisted Hugo Lloris may not even be on the bench as goalkeeper Brad Friedel will keep his place.
The France No 1 stopper, who joined Spurs from Lyon for £8 million on deadline day, was unhappy after being left out as second choice goalkeeper.
However, no fresh injury concerns for Spurs but Younes Kaboul, Scott Parker and Heurelho Gomes are all out with injuries.
Reading's Mali winger Jimmy Kebe is expected to return after missing most of the season with a hamstring injury.
*Spurs have managed to win just one of their last 11 Premier League away games.
*In their last encounter with Reading back in 2007, Spurs won 6-4 at White Hart Lane.
*Reading striker Pavel Pogrebnyak has scored seven goals from nine shots on target.
*Spurs forward Emmanuel Adebayor has scored six goals in his last six starts for Spurs.
Reading FC (4-4-1-1): Federici-Gunter, Pearce, Gorkkss, Harte-Karacan, Leigertwood, McAnuff, McCleary-Guthrie-Pogrebnyak
Tottenham (4-4-2): Freidel-Walker, Gallas, Vertonghen, Assou-Ekotto-Lennon, Sandro, Dembele, Bale-Dempsey, Adebayor