Unlike last season, when Wigan Athletic beat the Red Devils at home, Roberto Martinez's men have a tough task at Old Trafford this time around. The Latics have never beaten United at the Theatre of dreams.
Darren Fletcher returned to training but is unlikely to be match-fit but Wayne Rooney, Chris Smalling and Phil Jones are injured.
Veteran midfielder Ryan Giggs will make his 600th appearance in the Premier League, while Paul Scholes will touch 700 appearance for United and Rio Ferdinand's 400th start.
Wigan boss Martinez will have to reshuffle his back three with Antolin Alcaraz returning to replace Maynor Figueroa but Chilean winger Jean Beausejour is out with a hamstring injury.
*Manchester United have won 13 out of 14 Premier League games against Wigan Athletic.
*United are yet to keep a cleansheet this season.
*Wigan have won 8 out of their last 12 games but have conceded 24 goals at Old Trafford.
Manchester United (4-4-2): De Gea-Rafael, Ferdinand, Vidic, Evra-Valencia, Carrick, Cleverley, Nani-Kagawa-Van Persie
Wigan Athletic (3-4-3): Al-Habsi-Alcaraz, Caldwell, Ramis-Boyce, McCarthy, McArthur, Figueroa-Kone, Di Santo, Maloney