The Saints were close to upsetting both Manchester giants while they hope to trouble Arsenal at home. The Gunners are yet to score at home this season.
Southampton may start with club record signing Gaston Ramirez and new signing Maya Yoshida. Saints' Danny Fox and Jack Cork are expected to return to the first team after suffering injuries.
Arsenal goalkeeper Wojciech Szczesny will return to the starting XI after suffering a rib injury while midfielder Abou Diaby is a doubt with a minor knee problem.
Midfielders Tomas Rosicky, Jack Wilshere and Emmanuel Frimpong all continue their rehabilitation along with right-back Bacary Sagna.
*Arsenal's three consecutive cleansheets marks the clubs best start in 88 years.
*Southampton have failed to win in their last seven encounters against Arenal.
*The Saints have conceded atleast two goals in three games this season.
Arsenal (4-3-3): Sczcesny-Jenkinson, Vermaelen, Koscielny, Gibbs-Diaby, Arteta, Cazorla-Oxlade-Chamberlain, Giroud, Podolski.
Southampton (4-4-1-1): K Davis-Clyne, Hooiveld, Fonte, Fox-Schneiderlin, S. Davis, Ward-Prowse, Ramirez, Lambert-Lallana.