The drone struck a compound in Shawal area of North Waziristan, which has witnessed several missile strikes in the past few months. The CIA-operated spy plane fired two missiles at the compound.
Four persons were killed and two more injured in the strike, state-run Radio Pakistan reported. Inter-Services Intelligence chief Lt Gen Zahir-ul-Islam had raised Pakistan's demand for ending drone attacks during a recent visit to the US.
The Taliban recently banned polio vaccinations in North and South Waziristan, saying they would not be allowed as long as the US drone strikes continued.