The CIA-operated spy planes fired at least eight missiles at the compound and vehicle at Hassokhel, 25 km from Miranshah, the main town of North Waziristan Agency, which has been described by US officials as a stronghold of Taliban and al-Qaeda elements.
The drones struck early this morning and carried out two missile strikes on the target within half an hour, local residents said.
Foreign fighters, including Uzbeks and Arabs, are believed to be present in the area that was targeted. At least 23 militants have died in the drone attacks carried out in the past six days.
Four militants were killed in a drone strike on May 26 while four more were killed in an attack near Miranshah on May 23. Ten militants, mostly foreigners, were killed in yet another missile strike on May 24.
The US has stepped up drone strikes after the conclusion of the NATO Summit in Chicago last week, where Pakistan did not make any announcement about ending a nearly six-month blockade of supply routes to Afghanistan.
The supply lines were shut after a cross-border NATO air strike killed 24 Pakistani soldiers in November last year.
The string of drone strikes has added to tensions between the US and Pakistan, which has described the attacks as a violation of its sovereignty and called for them to be stopped.