The 84th ranked Indian lost 4-6, 3-6 in an hour and 27 minutes in his opening match of the $3,240,00 hard court tournament.
Now the head-to-head record of the two players stand 2-2 in four meetings this season.
Since Atlanta event in July, Somdev has competed in seven tournaments, including Davis Cup tie against Japan, and has won only two matches.
In the doubles event, Mahesh Bhupathi and Leander Paes are seeded fourth and have got a first round bye.
Rohan Bopanna and his Pakistani partner Aisam-ul-haq Quershi are seeded seventh and they also have got a first round bye.