The the talks will include international, regional and key bilateral issues and also include the current scenario in Pakistan and Afghanistan in addition to the security cooperation between the countries against the backdrop of recent terror blasts in Mumbai on Jul 13.
Hillary, who is on a two day visit will meet SM Krishna, External Affairs Minister apart from Prime Minister Manmohan Singh and Shiv Shankar Menon, National Security Adviser.
A breakfast meeting between Mrs Clinton and National Security Adviser will be held on Tuesday followed by talks on the Indo-US, after which the US Secretary is expected to meet senior political leaders and Sonia Gandhi, UPA Chairperson.
Hillary is also expected to meet representatives of US companies during her visit to Chennai.
India is also expected to hold talks on US' visa regime which to a large extent is hampering the movement of Indian IT professionals in America.