An electorate of over 74.17 lakhs will elect their representatives from among 193 candidates, including Health Minister and CPI(M) stalwart Suryakanta Mishra and WBPCC President Manas Bhunia.
Of the 38 seats, 12 are in West Midnapur, five in Purulia, nine in Bankura and 12 in Burdwan district.
The Left Front is contesting all the 38 seats while Trinamool Congress has fielded candidates in 33 and alliance partner Congress in five.
The BJP has fielded candidates in all the seats.
Tight security arrangements have been made to ensure peaceful polling with deployment of around 600 companies of central paramilitary forces besides state forces, according to election office sources here.
The Left Front's stake is high in these seats because during its rout at the hands of the Trinamool Congress in south Bengal in the 2009 Lok Sabha polls, the four districts, known as the red fort, rebuffed the winds of change blowing across Bengal.