Israel has retaliated strongly to an anti-tank missile strike by Gaza-based militants that hit a school bus injuring two persons, including a 16-year-old boy.
Israel Air Forces have struck from land and air across the coastal Strip.
The IAF resumed airstrikes on Gaza early this morning, responding to a barrage of mortar and rocket fire from the other side, targeting a private car in the Tel As-Sultan neighbourhood of Rafah in the southern part of the Strip, and several other sites across the coastal enclave, killing three and injuring dozens.
The deadliest strike hit the car of Hamas field commanders, killing Al-Qassam Brigades leader Taysir Abu Sneima and his assistant Muhammad Awaja and injuring critically a third militant identified as Shadi Az-Zatmah, medics in Gaza said.
Palestinian medical sources said the dead body of a third Hamas militant, identified as Ahmad Nabil Zaytouniyya, was evacuated to the Kamal Udwan Hospital in Beit Lahiya along with another man seriously injured in an 8:30 am strike today.
The early morning victims brought the death toll in the coastal enclave to 17 since Thursday, with more than 60 injuries, they said.
Six of the dead were identified as civilians.
Spokesman of the Gaza Strip's higher committee of ambulance and emergency service, Adham Abu Salmiya, told Palestinian news agency Ma'an that two dead bodies and a critically injured man were transferred to the Abu Yousif An-Najjar Hospital in Rafah.
In the northern Gaza Strip, Israeli warplanes targeted a car parked in the Ad-Daraj neighbourhood of Gaza City causing damage to several vehicles. No injuries have been reported in the blast.
A third strike targeted a Hamas training base in the Jabalya refugee camp in the northern Gaza Strip and another hit the Al-Umour neighbourhood in Khan Younis.
No injuries were reported in either of the hits. The border in Rafah with Egypt was also hit apparently targeting smuggling tunnels.
An Israeli military spokeswoman confirmed the strikes, saying the airforce had targeted overnight a terror activity site, a vehicle containing weaponry, wherein a secondary blast was detected on impact, three Hamas commanders in southern Gaza Strip and a smuggling tunnel near Rafah.
Hamas said it would work to "find a formula" that would stop the recent waves of Israeli air strikes after a unilateral ceasefire offer extended by it went unheard from Israel and militant factions in Gaza that continued to fire rockets and mortar shells.
"Israel has insisted on resuming its crimes against the Palestinians. It is a bid to control the resistance and the people of Gaza," a statement from the Hamas administration said calling upon rights organisations to "document crimes" so that charges could be laid.
The Islamist faction also reached out to the Arab world saying it was set to host an urgent meeting with the Arab League''s council to discuss "appropriate mechanisms" to face the recent escalation.
Meanwhile, Israel has claimed that its recently deployed Iron Dome anti-missile system intercepted three Grad rockets that were fired towards the city of Ashkelon.
In addition to the three intercepted rockets, one rocket fell in an open area near Ashkelon yesterday causing no injuries.
Israel's Defence Minister Ehud Barak praised the Israel Air Force and the defence industries responsible for the deployment of the Iron Dome missile defence system, commending them for using the system to successfully intercept rockets launched at southern Israel from Gaza.
"This is an exceptional achievement of the Israel defence industries and the air force," Barak said in a statement.