Washington, May 22 (ANI): Adult women who were exposed prenatally to bisphenol-A (BPA, a chemical commonly used in plastic food containers) or diethylstilbestrol (DES) could be at increased risk of breast cancer, according to a new study in mice.
Endocrine-disrupting chemicals are substances in the environment that interfere with hormone biosynthesis, metabolism or action resulting in adverse developmental, reproductive, neurological and immune effects in both humans and wildlife.
These chemicals are designed, produced and marketed largely for specific industrial purposes.
"BPA is a weak estrogen and DES is a strong estrogen, yet our study shows both have a profound effect on gene expression in the mammary gland (breast) throughout life," said Hugh Taylor, of the Yale University School of Medicine in New Haven, Conn. and lead author of the study.
"All estrogens, even 'weak' ones can alter the development of the breast and ultimately place adult women who were exposed to them prenatally at risk of breast cancer," Taylor added,
In this study, researchers treated pregnant mice with BPA or DES and then looked at the offspring as adults. When the offspring reached adulthood, their mammary glands still produced higher levels of EZH2, a protein that plays a role in the regulation of all genes. Higher EZH2 levels are associated with an increased risk of breast cancer in humans.
"We have demonstrated a novel mechanism by which endocrine-disrupting chemicals regulate developmental programming in the breast. This study generates important safety concerns about exposures to environmental endocrine disruptors such as BPA and suggests a potential need to monitor women exposed to these chemicals for the development of breast lesions as adults," said Taylor.
The study has been accepted for publication in Hormones and Cancer, a journal of The Endocrine Society. (ANI)