Yogurt-like drink DanActive cuts rate of common infections in daycare kids

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Washington, May 20 (ANI): The probiotic yoghurt-like drink DanActive can cut the rate of common sicknesses such as ear infections, sinusitis, the flu and diarrhoea in day-care children, according to researchers.

An additional finding, however, showed no reduction in the number school days missed.

Led by Daniel Merenstein of Georgetown University School of Medicine (GUSOM), the researchers studied the drink in the largest known probiotic clinical trial to be conducted in the United States.

Probiotic foods are continuing to increase in popularity and some are marketed for the potential benefits of probiotics such as Lactobacillus casei (L. casei) DN-114 001, the probiotic in DanActive.

Studies in other countries have found that probiotics, which are live micro-organisms, produce positive health benefits in children, including the reduction of school days missed due to infections.

However, most of the research was conducted outside the United States in structured conditions not comparable to normal everyday living.

"We were interested in a study that resembled how children in the U.S. consume drinks that are stored in home refrigerators and consumed without study personnel observation," said the study's lead author Dr. Daniel Merenstein, director of research in the Department of Family Medicine at GUSOM.

"...To our knowledge this is the largest probiotic clinical trial conducted in the U.S. and provides much needed data," say the authors of the study. "We studied a functional food, not a medicinal product; parents will thus feed their children without any physician input and we felt it was best to assess [the drink] under similar conditions," he added.

The study, titled DRINK (Decreasing the Rates of Illness in Kids), was a randomized, double-blind, placebo-controlled study - the gold standard in clinical research design.

It included 638 healthy children, aged three to six, who attended school five days a week.

Parents were asked to give their child a daily strawberry yogurt-like drink.

Some of the drinks were supplemented with the probiotic strain L. casei DN-114 001 (DanActive), while others had no probiotics (placebo).

Researchers found a 19 percent decrease of common infections among the children who drank the yogurt-like drink with L. casei DN-114 001 compared to those whose drink did not have the probiotic.

More specifically, those who drank DanActive had 24 percent fewer gastrointestinal infections (such as diarrhea, nausea, and vomiting), and 18 percent fewer upper respiratory tract infections (such as ear infections, sinusitis and strep).

However, the reduction in infections did not result in fewer missed school days or activities - also a primary outcome of the study.

"Our study had mixed results. Children in school or daycare are especially susceptible to these illnesses. We did find some differences in infection rates but this did not translate to fewer missed school days or change in daily activity. It is my hope that safe and tolerable ways to reduce illnesses could eventually result in fewer missed school days which means fewer work days missed by parents," said Merenstein.

"It is important that more of these products are put under the microscope by independent academic researchers," he concluded.

The study was published online in the European Journal of Clinical Nutrition. (ANI)

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