Expressing condolences to the victims, US has offered to help in the rebuilding process.
"We send our deepest condolences to families of the victims of the earthquake in China's Qinghai province. The American people are saddened by the loss of life and the devastation caused by this disaster," White House Press Secretary Robert Gibbs said in a statement.
"Our thoughts and prayers are with those injured or displaced, and all the people of China in this difficult period. We stand ready to assist in any way possible," he said.
Meanwhile, Secretary of State Hillary Clinton expressed US solidarity with people of China.
"On behalf of the American people, I offer sincere condolences to the families who lost loved ones in this morning's earthquake in China's southern Qinghai Province, Secretary of State Hillary Clinton said.
"Our thoughts and prayers are with those injured or displaced, and all the people of China on this difficult day. The US stands ready to assist," Clinton said.
Condolences continue to pour out from the US leaders with Speaker of the US House of Representatives Nancy Pelosi urging the people to stand in support of the quake victims.
"As Americans and as members of the international community, we must stand squarely behind the emergency response operations and rescue missions."
"Together, we can help the people of this region recover from this tragedy," Pelosi said in a statement.
"The thoughts and prayers of Members of Congress are with the people of China and Tibet, and the loved ones of those lost in the powerful earthquake that struck the region yesterday," Pelosi said.
International Monetary Fund (IMF) Managing Director Dominique Strauss-Kahn too offered his sympathy to the victims.
"On behalf of myself and my colleagues at the IMF, I would like to offer my sympathy to those affected by this devastating natural disaster."
"It was with great concern that I heard of the powerful earthquake that hit Qinghai province yesterday," Strauss-Kahn said in a statement.
"Our thoughts are with those who have lost loved ones and with the people of China as they work to recover from this terrible tragedy," he said in a statement.