The treaty is hailed as a major sign of improved bilateral relations between the world's two leading nuclear powers.
This intends to send a strong signal to the world that Russia and the US are serious about disarmament.
Both Presidents say that the new cuts in the largest arsenals on the planet are a step toward a world without nuclear weapons and a signal to nations seeking them that there is no need.
The treaty will reduce the number of long-range deployed nuclear warheads by 30 percent.
The treaty is also a successor to the 1991 Strategic Arms Reduction Treaty (START), which expired last Dec 2009.