Scientists use tiny worms to unlock keys to herbal meds

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Washington, Mar 28 (ANI): University of Maryland, Baltimore (UMB) researchers have developed a biologic method to tease out which compounds from herbal medicines and medicinal herbal mixtures produce their reputed medicinal benefits.

The boffins reported the development in the science journal PLos ONE.

"This provides the first step to find, from all of the hundreds of compounds in herbs, which ones have potential for medicinal purposes. And you can do this very quickly and efficiently," said co-author Laura Dosanjh, graduate student with the School of Pharmacy at UMB.

Using tiny worms that live only 20 days, the team sorted out which compounds found in two common Chinese herbal formulations showed most potential for their stated purpose: extending life expectancy.

Cinnamon and ginseng won, showing the most promise.

A team led by Yuan Luo PhD, MS, associate professor at the School, conducted a first-of-its- kind, "systematic evaluation" of a mixture of 10 herbs called Shi-Quan-Da-Bu-Tang (SQDB), reportedly effective for fatigue and energy; and an 11-herb formula called Huo Luo Xiao Ling Dan (HLXL) used as a the treatment of arthritic joint pain. Both mixtures are reputed to have benefits for healthy living and longevity in humans.

The researchers tested the mixtures, as well as each separate herb in them, on the laboratory worm model C. elegans. This particular worm-which biochemists often use as their 'lab rat', shares genes for aging and other traits with humans and other organisms.

Cinnamon bark (Cinnamomum cassia) from HLXL extended life span of the worms by 14.5 percent and cinnamon bark from SQDB extended the life 10.8 percent.

Ginseng root (Panax ginseng) from SQDB extended life span by 7.7 percent. Ginseng is not an ingredient in HLXL.

Significantly, cinnamon, ginseng, and SQDB also thinned out levels of hydrogen peroxide, which can destroy cells. They each also enhanced expression of small heat shock proteins, an indicator for cellular response to stress that plays an important role in maintenance of cell functions.

Furthermore, the life span-extending herbs appreciatively reduced in the expression in C. elegans of a toxicity factor, amyloid, which is a hallmark in the human brain of pathological evelopment of Alzheimer's disease. (ANI)

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