Addressing a press conference, Yang said, "The responsibility does not lie with China."
China and US have recently gone through a rough patch, with quarrels in Jan and Feb 2010.
Those include Chinese Internet censorship, trade disputes, US arms sales to Taiwan, and President Barack Obama's meeting with the Dalai Lama, the exiled Tibetan leader.
"The United States must respect China's core interests on Taiwan and Tibet," Yang said.
He further said, "China has always attached importance to its relationship with the United States."
"I believe the United States understands very well China's core interests and major concerns," he added.