London, Nov 28 (ANI): Ever thought of being as dirty as a pig? Well, such a lifestyle could be helpful, says a research that has shown how dirty piglets obtain 'friendly' bacteria that help them to develop healthy immune systems later in life.
The results of the study provide the first direct link between dirty living, immune health and genetic expression.
They also indicate that manipulating gut bacteria early in life might reduce allergies and other autoimmune diseases, said Denise Kelly, a gut immunologist at the University of Aberdeen, UK and one of the study's authors.
The study began with 54 piglets and divided them equally between an outdoor environment, an indoor environment, and an isolated environment where they were fed antibiotics on a daily basis.
The scientists then killed piglets on days 5 (neonatal stage), 28 (weaning age), and 56 (nearing maturity) to study their gut tissue and faeces.
It was found that 90 percent of bacteria in the guts of the outdoor piglets came from the phylum Firmicutes.
Most of these were lactobacillaceae, known for their health-promoting effects, and for their ability to limit intestinal pathogens such as Escherichia coli and Salmonella.
On the other hand, the Firmicutes bacteria made up less than 70 percent and just more than 50 percent of the gut flora in indoor and isolated bred pigs respectively.
The pigs also had much smaller proportions of bacteria from the lactobacillaceae family.
The researchers also found that the differences in gut microbial communities affected the expression of genes associated with the piglets' immune system.
Animals raised in the isolated environment expressed more genes involved in inflammatory immune responses and cholesterol synthesis, whereas genes associated with T cells were expressed in the outdoor-reared pigs.
Kelly said that until now, the link between living environment and immune response had been circumstantial.
"There has been a lot of hearsay around gut microbiota and how it influences immune function and susceptibility to diseases and allergies," Nature quoted her as saying.
The latest work establishes a strong causal link.
However, Glenn Gibson, a food microbiologist at the University of Reading, UK, said that because the study was carried out in pigs, it is not certain that the results are relevant to humans.
Kelly argues that the similarities between the organisms found in human and pig guts and their comparable size in organs, makes pigs a good model animal to study.
The study has been published in BMC Biology1. (ANI)