Brain structures behind emotional balance in threatening situations identified

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Washington, Oct 22 (ANI): A primitive region of the brain, which is behind sensorimotor control, also plays an important role in regulating emotional responses to threatening situations, say researchers at Georgetown University Medical Center.

This region appears to work in concert with another structure called the amygdala to regulate social and emotional behaviour.

The researchers have recently discovered that activation of a primitive brain region, the deep layers of superior colliculus (DLSC), elicits defensive behaviours such as an exaggerated startle, hypervigilance, cowering, and escape.

They have said that a prolonged activation of this defense system may lead to emotional disorders.

The researchers said that in addition to triggering defensive behaviours, the activation of DLSC leads to a decrease in affiliative social interactions.

Typically, social interactions are thought to be domain of the amygdala, a region known to work closely with high-level executive structures to regulate emotional processes.

They have said that there is no information about possible interactions between the amygdala and DLSC for regulating social and emotional responses.

They decided to try simultaneously activating DLSC while inhibiting the amygdala, which made them discover that the manipulations cancelled each other out.

"These results suggest that the amygdala and DLSC interact to modulate emotional and social behaviours, either directly, or indirectly by converging on a common target in the brain.

The understanding of the functional interaction between these two brain structures is expected to reveal novel targets for therapeutic intervention for post traumatic stress disorder and other anxiety disorders," said Ashley Decker, a research assistant in the pharmacology department at GUMC, and now a student at the Georgetown University School of Medicine.

The study was presented at the 39th annual meeting of the Society for Neuroscience. (ANI)

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