Senator John Kerry statements came after a meeting with Pakistani Foreign Minister Shah Mehmood Qureshi.
Speaking to reporters here, Kerry said, "There is nothing in this bill that impinges on Pakistani sovereignty - period, end of issue. And we have no intention of doing so."
"The bill doesn't have to be changed. If there is a misinterpretation, it simply has to be clarified," he said.
The bill, which Mr Kerry co-authored with Senator Richard Lugar, triples non-military aid to Pakistan to an annual outlay of $1.5bn for five years.
The US also has to certify that Pakistan is no longer supporting militant groups. The aid money will be spent on various development projects.