Funded in 1999, the NGO supports disadvantaged children.
Bangalore with its theme, Tweet, meet and give, is one among 200 cities worldwide celebrating the Twitter Festival on the same day.
"We are doing a rockshow by Indian rock band 'Swarathma' at Kyra in Indiranagar," said Bangalore event coordinator Hrish Thota.
"The event will be ticketed at a reasonable price and we are getting a prominent cut out of it that we will donate to the charity. We will have presentations from the charity on their work."
The other Indian cities having Twesival are Delhi, Chennai, Mumbai, Kolkata, Hyderabad and Pune.
Twestival, originating in London, Sep 2008, is held worlwide twice a year - once for a global cause in February and for a local cause in September.
"Twestival Local, like the one that is happening on Saturday, is a great opportunity to connect with people in the community," said Vaijayanthi K M, Regional coordinator for Twestivals in India, Bangladesh and Middle East.
"The aim is to give people a chance to feel they are contributing to a larger social initiative, but bring the cause a little closer to home."