Zardari was known to be a bad guy long before he became Pakistan's President. Many of the closest friends of his late wife, Benazir Bhutto, could not stand him.
Now, as it turns out, neither can most of the Pakistani people, the magazine stated.
According to the magazine, Zardaris giving in to the demands of former Prime Minister Nawaz Sharif's of reinstating the judiciary and particularly former Chief Justice Iftikhar Muhammad Chaudhry has made him weaker.
Hes on the ropes, his opposition is gaining strength, and meanwhile fraught, dangerous, complex Pakistan is hardly being governed at all, the magazine said.
Other biggest losers in the list are US Democratic Senator, Chris Dodd at number four, US swindler Bernie Madoff at number three, and the Roman Catholic Pope on the second spot for his out of touch with the real world view.
Austrian businessman, Josef Fritzl has been ranked the number one loser.