Washington, Sept 23 : A calorie-restricted diet does not appear to induce bone loss in young, overweight adults, according to a report in the September 22 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.
However, adequate amounts of calcium and other nutrients have to be maintained to reap the benefits.
Calorie restriction is the only intervention known to decrease the rate of biological aging and increase longevity, according to background information in the article. However, it is well known that chronic energy deficiency impairs bone mineral uptake and that weight loss is associated with bone loss in obese individuals.
Calorie restriction, therefore, could also lead to bone loss and fracture.
To reach the conclusion, Leanne M. Redman, Ph.D., and colleagues at Pennington Biomedical Research Center, Baton Rouge, La., studied 46 healthy, overweight men and women (average age 37) who were randomly assigned to one of four groups for six months.
Eleven formed the control group, assigned to eat a healthy diet; 12 were assigned to consume 25 percent fewer calories than they expended per day; 12 were assigned to create a 25 percent energy deficit through eating fewer calories and exercising five days per week; and 11 ate a low-calorie diet (890 calories per day) until they achieved 15 percent weight loss, at which time they switched to a weight maintenance plan.
All diets included recommended levels of vitamins and minerals, including calcium, and contained 30 percent fat, 15 percent protein and 55 percent carbohydrates, based on American Heart Association guidelines.
After six months, average body weight was reduced by 1 percent in the control group, 10.4 percent in the calorie restriction group, 10 percent in the calorie restriction plus exercise group and 13.9 percent in the low-calorie diet group.
Bone mineral density and blood markers of bone resorption and formation (processes by which bone is broken down and regenerated on a regular basis) were measured at the beginning of the study and again after six months.
"Compared with the control group, none of the groups showed any change in bone mineral density for total body or hip," the researchers said.
Markers of bone resorption were increased in all three intervention groups, while markers of bone formation were decreased in the calorie restriction group but were unchanged in the low-calorie diet or calorie restriction plus exercise group.