Scientists develop portable device to zap away migraine pain

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Washington, June 27 : Researchers at the Ohio State University Medical Center have designed a novel electronic device that effectively 'zaps' away migraine pain before it starts.

The results are based on a study, which showed that the experimental device is safe and effective in eliminating headaches when administered during the onset of the migraine.

Dr. Yousef Mohammad, a neurologist and principal investigator of the study at Ohio State's Medical Center, said that the results are promising given that only 50 to 60 percent of migraine patients respond to traditional migraine drug treatments.

The noninvasive transcranial magnetic stimulator (TMS) device interrupts the aura phase of the migraine, often described as electrical storms in the brain, before they lead to headaches.

Migraine sufferers often describe 'seeing' showers of shooting stars, zigzagging lines and flashing lights, and experiencing loss of vision, weakness, tingling or confusion, followed by intense throbbing head pain, nausea and vomiting.

Previous studies, conducted at Ohio State, using a heavy and bulky TMS device, reduced headache pain. To expedite treatment at home, a portable hand-held device was developed and tested.

"Stimulation with magnetic pulses from the portable TMS device proved effective for the migraine patients. Because of the lack of adverse events in this trial and the established safety of the TMS device, this is a promising treatment for migraines with aura. This sets the stage for future studies in migraines without aura," Mohammad said.

The TMS device sends a strong electric current through a metal coil, which creates an intense magnetic field for about one millisecond.

This magnetic pulse, when held against a person's head, creates an electric current in the neurons of the brain, interrupting the aura before it results in a throbbing headache.

"The device's pulses are painless and safe. Since almost all migraine drugs have some side effects, and patients are prone to addiction from narcotics, or developing headaches from frequent use of over-the-counter medication, the TMS device holds great promise for migraine sufferers," Mohammad said.

Of the 164 patients involved in the multi-center, randomised clinical trial receiving TMS treatment, 39 percent were pain free at the two-hour post-treatment point, compared to 22 percent in the group receiving "sham" pulses.

There were no differences reported related to adverse reactions between the two groups.

It was previously believed that migraine headaches start with vascular constriction, which results in an aura, followed by vascular dilation that will lead to a throbbing headache.

However, in the late 1990's it was suggested that neuronal electrical hyperexcitablility resulted in a throbbing headache.

This new understanding of the migraine mechanism helped in the development of the TMS device.

The study has been presented at the annual American Headache Society meeting in Boston.

ANI

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