Washington, April 8 : A new study has shown that a proprietary blend extracted from canola, Dermytol(tm), produces a pronounced reduction in malignant melanoma cell growth.
Dermytol(tm), a proprietary compound developed by KGK Synergize Inc., a biotechnology company in Ontario Canada, is designed to protect skin cells from damage that may lead to skin cancer.
"Dermytol(tm) has the potential to be used in anti-aging and sun-protection products to reduce damage to skin," Mal Evans, DVM, MSc, PhD, KGK Synergize Inc's Scientific Director, said.
To test the effects of Dermytol(tm), researchers fed male mice with either a Dermytol(tm)-canola oil mixture or just canola oil.
In a separate part of the study, either a Dermytol(tm) cream or a placebo cream was applied onto the shaved skin of a different group of mice.
After seven days of treatment, researchers injected all the mice with malignant melanoma tumour cells.
Dermytol(tm) or placebo treatments continued for 25 days.
Researchers found that the mice in both Dermytol(tm) groups benefited from their treatments.
The orally treated mice showed an average decrease in tumour size by about 45 percent as compared to the controls.
Researchers found that mice receiving the topical treatment had a 61 percent decrease in tumour volume.
In this study and previous studies, Dermytol(tm) showed no adverse effects.
In a laboratory cell culture study, Dermytol(tm) inhibited the proliferation of human cancer cells.
In a separate study, dietary supplementation with Dermytol(tm) moderately delayed the onset of skin tumours and significantly reduced tumour growth rate in mice treated to induce non-melanoma skin cancers.
A trial including 45 subjects with actinic keratoses - precancerous skin lesions - is underway.
"The current treatment for actinic keratoses is removal by freezing which can be painful or the application of a cream that causes inflammation and blistering of the skin. We expect Dermytol(tm) to be a welcome option," Evans said.
The study was presented at the Experimental Biology Annual Meeting.