Washington, Mar 2 : A new study by researchers at the Radboud University Nijmegen Medical Center in The Netherlands has found that the majority of patients with narcolepsy/cataplexy experience a number of symptoms of eating disorders, with an irresistible craving for food and binge eating as the most prominent features.
Hal Droogleever Fortuyn, MD, and Sebastiaan Overeem, MD, of the Radboud University Nijmegen Medical Center in The Netherlands, examined 60 patients with narcolepsy/cataplexy who were recruited from specialized sleep centres and 120 healthy controls.
The researchers found that 23.3 percent of the narcolepsy/cataplexy patients fulfilled the criteria for a clinical eating disorder, as opposed to none of the control subjects.
They found that 50 percent patients reported a persistent craving for food, as well as binge eating. Twenty-five percent of patients even reported binging at least twice a week.
"These data make it clear that narcolepsy is not just a sleeping disorder, but a hypothalamic disease with a much broader symptom profile," Dr. Fortuyn said.
"Hypocretin, the neurotransmitter that is lost in narcolepsy, has been implicated in the regulation of feeding through animal studies. Earlier studies in narcolepsy found a clear increase in body weight. However, we did not find a correlation between binge eating and increased weight.
"Binge eating is apparently not the direct cause of the obesity in narcolepsy, and this suggests that metabolic alterations may be involved.
"Nevertheless, our study shows that the loss of hypocretin function makes narcolepsy patients not only struggle with staying awake, but also destabilizes their eating pattern, which makes it harder to stay away from the candy jar," Dr. Fortuyn added.
The study is published in the March 1 issue of the journal SLEEP.