Bacteria in newborn airways may raise asthma risk
NEW YORK, Oct 11 (Reuters) Newborns who harbor certain types of bacteria in their throats, including Streptococcus pneumoniae, a common cause of pneumonia, and Haemophilus influenzae, which causes upper respiratory infections, are at increased risk for developing recurrent wheeze or asthma early in life, new research shows.
This finding ''opens new perspectives for the understanding and prediction of recurrent wheeze and asthma in young children,'' lead author Dr. Hans Bisgaard, from Copenhagen University Hospital in Denmark, and colleagues conclude in their report in The New England Journal of Medicine for today.
The researchers assessed the development of recurrent wheeze and asthma in 321 newborns who had throat cultures taken at 1 month of age and who were then followed through 5 years of age.
Twenty-one percent of infants were colonized with S pneumoniae, H influenzae, another type of bacteria called M catarrhalis, or a combination of these bugs and this finding more than doubled the risk of persistent wheeze, wheeze flare-up, and hospitalization for wheeze.
The prevalence of asthma at age 5 was significantly increased in the children who harbored these organisms as newborns compared with children who did not (33 per cent versus 10 per cent), the investigators report.
In
a
related
editorial,
Dr
Erika
von
Mutius,
from
University
Children's
Hospital
in
Munich,
Germany,
comments
that
these
findings
may
be
interpreted
to
suggest
that
the
presence
and
growth
of
bacteria
in
the
throat
in
the
first
4
weeks
of
life
''indicates
a
defective
innate
immune
response
very
early
in
life,
which
promotes
the
development
of
asthma.''
Thus,
she
adds,
the
researchers
''may
have
found
an
interesting
and
new
sentinel
rather
than
a
causative
signal.''
REUTERS
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